Congratulations！
Congratulations to jia Lin for our recent publication on Chinese Chemical letters. Link: https://doi.org/10.1016/j.cclet.2025.112100
Hydrogen sulfide (H2S) is a pivotal endogenous gaseous signalling molecule involved in various physiological processes. Although H2S exhibits significant anti-inflammatory effects at physiological concentrations, its clinical utility is hindered by the challenges associated with its high activity and difficulties in controlled release. We designed three photoactivatable H2S donors, HSDs (HSD1, HSD2, and HSD3), by integrating an H2S-releasing 1,4,2-dioxazole-5-thione scaffold with three fluorophores spanning the ultraviolet to red spectral range. Upon photo-irradiation, each donor induces a pronounced turn-on fluorescence (>58-fold), accompanied by efficient H2S release (over 30 %) without the formation of electrophilic by-products. Moreover, HSDs enable real-time quantitatively photo-triggered H2S-release in both live cells and murine models, and present anti-inflammatory and antioxidant effects in vivo. In a full-thickness cutaneous wound model, HSDs markedly accelerated wound healing, highlighting their potential as precision therapeutic agents for wound management. Collectively, we provide a translatable strategy to overcome the limitations of conventional H2S delivery systems and highlight the therapeutic promise of controlled H2S release in clinical application.
